Estimating Linkage Disequilibrium Between a Polymorphic Marker Locus and a Trait Locus in Natural Populations
نویسندگان
چکیده
منابع مشابه
Estimating linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations.
Positional cloning of gene(s) underlying a complex trait requires a high-resolution linkage map between the trait locus and genetic marker loci. Recent research has shown that this may be achieved through appropriately modeling and screening linkage disequilibrium between the candidate marker locus and the major trait locus. A quantitative genetics model was developed in the present study to es...
متن کاملInferring linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations.
Three approaches are proposed in this study for detecting or estimating linkage disequilibrium between a polymorphic marker locus and a locus affecting quantitative genetic variation using the sample from random mating populations. It is shown that the disequilibrium over a wide range of circumstances may be detected with a power of 80% by using phenotypic records and marker genotypes of a few ...
متن کاملModeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations.
Linkage disequilibrium is an important topic in evolutionary and population genetics. An issue yet to be settled is the theory required to extend the linkage disequilibrium analysis to complex traits. In this study, we present theoretical analysis and methods for detecting or estimating linkage disequilibrium (LD) between a polymorphic marker locus and any one of the loci affecting a complex di...
متن کاملSelective DNA pooling for determination of linkage between a molecular marker and a quantitative trait locus.
Selective genotyping is a method to reduce costs in marker-quantitative trait locus (QTL) linkage determination by genotyping only those individuals with extreme, and hence most informative, quantitative trait values. The DNA pooling strategy (termed: "selective DNA pooling") takes this one step further by pooling DNA from the selected individuals at each of the two phenotypic extremes, and bas...
متن کاملHaplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations.
Because defects in the phenylalanine hydroxylase gene (PAH) cause phenylketonuria (PKU), PAH was studied for normal polymorphisms and linkage disequilibrium soon after the gene was cloned. Studies in the 1980s concentrated on European populations in which PKU was common and showed that haplotype-frequency variation exists between some regions of the world. In European populations, linkage diseq...
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ژورنال
عنوان ژورنال: Genetics
سال: 1999
ISSN: 1943-2631
DOI: 10.1093/genetics/151.1.359